解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::A method for stimulating sensitized lymphocytes by inactivated herpes simplex virus was established by using cultures of washed whole blood cells. The development of the immune response of herpes simplex virus-infected guinea pigs was examined at different times in the 4-month period after infection. Humoral and cellu...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.10.3.430-436.1974
更新日期:1974-09-01 00:00:00
abstract::The purpose of our experiment was to evaluate the destructive potential of a strain of Actinomyces viscosus on the periodontium of sensitized rodents, describing the induced lesions on the basis of quantitative cytology. The experimental design comprised in principle the following procedures. Young germfree rats were ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.10.3.565-577.1974
更新日期:1974-09-01 00:00:00
abstract::The inhibition by Mycoplasma dispar of ciliary activity of organ cultures of bovine fetal trachea was found to be dependent on the presence of serum in the maintenance medium. Inhibitory activity was unaffected by catalase and no toxic substance was demonstrated in organ culture supernatant fluid. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.10.2.405-408.1974
更新日期:1974-08-01 00:00:00
abstract::Pretreatment with multiple doses of polymyxin B and colistimethate was evaluated as to its ability to sequester sufficient antibiotic in tissues to neutralize the effects of endotoxin in three animal models. Animals were challenged with endotoxin 24, 48, or 72 h after the last dose of antibiotic when there was minimal...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.10.2.287-292.1974
更新日期:1974-08-01 00:00:00
abstract::Comparative studies on the virulence of two strains of Pseudomonas aeruginosa isolated from otic pus and mink pneumonic lesion, respectively, were made by means of intranasal inoculation in mink. The minimal lethal dose of the former (strain NC-5, highly virulent for mice) was 10(10), and that of the latter (strain No...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.10.1.16-20.1974
更新日期:1974-07-01 00:00:00
abstract::Isolates of Thermoplasma acidophilum were divided into serological groups based on immunodiffusion studies of solubilized-membrane preparations. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.10.1.280-281.1974
更新日期:1974-07-01 00:00:00
abstract::Chromatographic analysis, coupled to mass spectrometry with a high-resolution mass spectrometer, of materials isolated from skin lesions of patients with lepromatous leprosy allows the recognition of characteristic mycobacterial products, mycolic acids. This finding indicates that the "noncultivable" bacteria responsi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.10.1.236-239.1974
更新日期:1974-07-01 00:00:00
abstract::Peroxidase-conjugated antibodies were found to be as sensitive as those conjugated to fluorescein-isothiocyanate (FITC) for identification of selected enterovirus types by the indirect technique. Peroxidase conjugates, however, were found to give fewer nonspecific reactions. The reasons for the higher specificity of t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.10.1.220-226.1974
更新日期:1974-07-01 00:00:00
abstract::Biological properties of two strains of simian virus 40 (SV40) from brains of two patients with progressive multifocal leukoencephalopathy (PML) have been compared to those of a standard laboratory strain of SV40. Infectivity of both SV40-PML viruses was resistant to treatment with chloroform, low pH, and 50 C for 120...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.10.1.173-179.1974
更新日期:1974-07-01 00:00:00
abstract::The interferon-inducing capabilities of the three molecular segments of bacteriophage phi6 double-stranded ribonucleic acid increased with increasing molecular weight. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.10.1.284-285.1974
更新日期:1974-07-01 00:00:00
abstract::A study of the rise and fall in circulating tetanus antitoxin in a group of 15 adults after basic and booster immunization indicates that although individuals vary greatly in their responsiveness to toxoid, the falloff in antitoxin appears to be fractionally constant for each individual, and over periods of 5 to 6 yea...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.10.1.1-5.1974
更新日期:1974-07-01 00:00:00
abstract::The action of trehalose-6, 6'-dimycolate (cord factor) of Mycobacterium tuberculosis to induce site II-specific inhibition of mitochondrial oxidative phosphorylation and to stimulate adenosine triphosphatase activity was neutralized by its specific antibody. The activity was restored after dissociation of cord factor ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.10.1.277-279.1974
更新日期:1974-07-01 00:00:00
abstract::The American opossum is the only experimental animal that regularly develops bacterial endocarditis spontaneously. There was no relation between the ability of opossums to clear bacteria from the bloodstream and the subsequent development of endocarditis. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.6.1126-1128.1974
更新日期:1974-06-01 00:00:00
abstract::The response of ferrets after intranasal inoculation of inactivated A/Hong Kong/68 (H3N2) influenza virus vaccines is reported. Normal ferrets given either saline vaccine in drops or freeze-dried vaccine in an aerosol intranasally did not produce detectable serum or nasal hemagglutination inhibiting antibody and were ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.6.985-990.1974
更新日期:1974-06-01 00:00:00
abstract::During the process of phagocytosis, human leukocytes emit a burst of luminescence which can be measured in a liquid scintillation spectrometer. The enzyme superoxide dismutase, which removes superoxide anions (O(2.)), inhibited this chemiluminescence by 70% at a concentration of 100 mug/ml. The enzyme did not inhibit ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1974-06-01 00:00:00
abstract::Rickettsia rickettsii and R. australis formed infectious antibody complexes when reacted with homologous convalescent serum. The addition of antiglobulin to these complexes showed neutralization of plaques proportional to the concentration of rickettsial immune serum. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.5.966-968.1974
更新日期:1974-05-01 00:00:00
abstract::Deoxyribonucleic acid (DNA) base composition, as measured by guanine plus cytosine (G + C) content, was determined in 17 strains of Sporothrix schenckii and Ceratocystis species. The average G + C content for S. schenckii was 54.7 +/- 0.2 mol%. No strain of Ceratocystis, with the exception of C. minor, gave values for...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.5.934-938.1974
更新日期:1974-05-01 00:00:00
abstract::In experiments described herein, it was observed that guinea pigs with delayed-type hypersensitivity to tuberculoproteins under various experimental conditions, with or without passive transfer of serum from immune donors, manifested no acquired immunity against aerogenically induced tuberculosis. These results are di...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.5.815-820.1974
更新日期:1974-05-01 00:00:00
abstract::Ten cultures of Mycobacterium tuberculosis, one of Mycobacterium kansasii (nonsignificant), and one of Mycobacterium phlei were submitted to starvation. As a result they lost first their acid fastness and then all other staining affinities but, in this chromophobic state, they survived for at least 2 years and, after ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.5.843-850.1974
更新日期:1974-05-01 00:00:00
abstract::Lipopolysaccharides obtained from Brucella abortus, B. melitensis, and B. suis, but not B. canis, were found to contain amino sugars identified as glucosamine and quinovosamine by cation exchange and thin-layer cellulose chromatography and ninhydrin degradation. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.4.772-774.1974
更新日期:1974-04-01 00:00:00
abstract::The predominant gram-positive bacteria in 47 fecal specimens from 10 healthy men were studied by microscopic and cultural counts, by the characterization and tentative identification of isolates, and by the use of fluorescein isothiocyanate (FITC)-conjugated globulins prepared using some of the isolates. Gram-positive...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.4.719-729.1974
更新日期:1974-04-01 00:00:00
abstract::Live or heat-killed cells of Streptococcus mutans specifically adhere to dextran previously synthesized on glass surfaces by the action of extracellular dextransucrase. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.4.764-765.1974
更新日期:1974-04-01 00:00:00
abstract::Rickettsia prowazeki, pretreated with typhus immune human serum, readily infects, and grows in, chicken embryo cells in culture. This finding is similar to those of previous studies which showed that typhus rickettsiae, pretreated with immune serum, grow in cells of the yolk sac of embryonated hen eggs and in the cell...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.3.571-575.1974
更新日期:1974-03-01 00:00:00
abstract::Mouse peritoneal macrophages were infected with varying numbers of Nocardia asteroides 10905, and the fate of the ingested organisms was determined by viable plate count (VPC), light microscopy (LM), immunofluorescent microscopy (IM), and electron microscopy (EM). The results obtained with these methods differed. VPC ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.3.576-590.1974
更新日期:1974-03-01 00:00:00
abstract::Ribosomal subunits from Mycobacterium smegmatis were analyzed by using sedimentation velocity, sedimentation equilibrium, and acrylamide gel electrophoresis experiments. These s(20.w) values for the subunits are 48.7S and 28.1S. The molecular weight of the 49S subunit is about 1.65 x 10(6), and that of the 28S subunit...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.3.489-496.1974
更新日期:1974-03-01 00:00:00
abstract::The mechanism of adsorption of the Streptococcus mutans enzymes responsible for the synthesis of insoluble dextran-levan to the S. mutans cell-wall binding sites has been studied. Certain characteristics of these binding sites are presented. The adsorption of these enzymes to the cell surface occurred rapidly without ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.2.419-429.1974
更新日期:1974-02-01 00:00:00
abstract::Rinderpest virus infection was shown to induce marked suppression of both humoral antibody response and cell-mediated immunity in rabbits. The virus exhibited a suppressive effect on primary antibody response as indicated by a decrease in numbers of plaque-forming cells (immunoglobulin [Ig]M) and hemagglutinating anti...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.2.206-211.1974
更新日期:1974-02-01 00:00:00
abstract::Because combined administration of intramuscular and intravenous interferon has been partially successful in the incubationary treatment of rabies, the effect of direct interferon administration into the cerebrospinal fluid space was tested. After injecting 1,800 U of interferon into the cisterna magna or the lateral ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.2.286-293.1974
更新日期:1974-02-01 00:00:00
abstract::Tubercle bacilli failed to grow in iron-void media enriched with solutions of iron-containing transferrin (Tr) or ferritin (F) because these substances do not provide the bacilli with iron, which is essential for their growth. Animal serum and macrophages possessed no iron carrier with an ability to satisfy the need o...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.1.34-40.1974
更新日期:1974-01-01 00:00:00
abstract::Lipid compositions of 40 patient isolates of Mycobacterium tuberculosis derived from Madras, Burma, Rangoon, and East Africa were studied, and two major populations of tubercle bacilli were distinguished. Nearly all of the strains previously designated as attenuated for the guinea pig (D. A. Mitchison) are characteriz...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.1.150-158.1974
更新日期:1974-01-01 00:00:00
abstract::Eight chlamydial isolates of ovine origin were tested in a plaque reduction system using homologous and heterologous rooster antisera. The eight isolates could be separated into two separate immunotypes. Type 1 included isolates associated with ovine abortion and one agent recovered from the feces of an apparently nor...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.1.92-94.1974
更新日期:1974-01-01 00:00:00
abstract::The abilities of six strains of Mycobacterium bovis strain BCG to replicate in vivo and to cause spleen enlargement in the CDF(1) male mouse were compared. The strains were grown in synthetic medium and harvested soon after complete pellicles were produced on liquid medium. In addition, two freeze-dried commercially a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.8.5.736-742.1973
更新日期:1973-11-01 00:00:00
abstract::A defect in lymphocyte function could be responsible for persistent infection by the equine infectious anemia virus. The number of lymphocytes bearing surface immunoglobulin, as detected by immunofluorescence, and lymphocyte response to mitogens were the same in uninfected and equine infectious anemia-infected animals...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.8.4.679-682.1973
更新日期:1973-10-01 00:00:00
abstract::An apparent inhibition of induction of mouse hepatic tryptophan oxygenase by endotoxin has been reported previously, as evidenced by low catalytic activity. This could be due either to decreased tryptophan oxygenase levels or to inactivation of existing enzyme molecules. To resolve this question, the enzyme was quanti...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.8.4.534-539.1973
更新日期:1973-10-01 00:00:00
abstract::Brucella abortus and polyacrylic acid, two agents whose interferon-inducing capacity in the mouse has been well established, failed to stimulate circulating interferon production in rabbits, yet protected rabbits against local vaccinia virus infection. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.8.4.669-673.1973
更新日期:1973-10-01 00:00:00
abstract::An analysis of which component of lipopolysaccharide, the lipid or the polysaccharide, is mitogenic for mouse B-lymphocytes has been performed. A purified glycolipid derived from a rough mutant of Salmonella minnesota (R595) that does not contain any o-polysaccharide at all is more mitogenic than an intact lipopolysac...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.8.3.406-411.1973
更新日期:1973-09-01 00:00:00
abstract::The relationship of catalase, cystinase, and deoxyribonuclease activity to toxinogeny in Corynebacterium diphtheriae was examined. Mutants deficient in each activity were isolated after mutagenization of strain C4 with nitrosoguanidine. All mutants were converted to toxinogeny after lysogenization with beta-converting...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.8.3.442-445.1973
更新日期:1973-09-01 00:00:00
abstract::Whole blood and plasma from animals in the acute stage of leptospirosis contained a toxic factor which produced a cytopathic effect on fibroblastic L cell monolayers. Firm adsorption of cytotoxic factor (CTF) to L cells occurred within 1 h. The highest titer of CTF in plasma was reached at 24 h and declined after 48 h...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.8.3.401-405.1973
更新日期:1973-09-01 00:00:00
abstract::Rabbit synovial cells (SC), articular chondrocytes (AC), and epiphyseal (EC) chondrocytes were grown in vitro. A portion of the spectrum of human pathogenic viruses infective for the cells was determined. Responses of the cells to different viruses or a chemical inducer of interferon varied, with EC responding vigorou...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.8.3.425-429.1973
更新日期:1973-09-01 00:00:00
abstract::An "immunogenic" ribonucleic acid (Im-RNA) has been extracted from peritoneal exudate (PE) cells of rats that were immunized with sheep erythrocytes (SRBC). Following multiple phenol extractions and deoxyribonuclease treatment, the material obtained from PE cells was eluted from diethylaminoethyl-cellulose at 0.55 M N...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.8.2.215-221.1973
更新日期:1973-08-01 00:00:00